Principles and Methods of ToxicologyAndrew Wallace Hayes Raven Press, 1982 - 750 páginas Hefty and authoritative, the new edition of this reference and text (suitable for graduate level teaching) contains 37 contributed chapters arranged in sections on principles, agents, and methods of toxicology. They provide a state-of-the-art exposition of information related to the task of identifying whether or not a causal relationship exists between specific doses of a chemical and an alleged adverse effect. Current testing procedures, guidelines on data interpretation, and areas of current controversy are covered; new chapters in this edition expand coverage of epidemiology, exposure assessment, and repeat dosing. Editor Hayes is an executive in charge of product integrity at The Gillette Company; contributors are from companies and institutions all over the US. c. Book News Inc. |
Conteúdo
Principles and Methods for Acute and Subchronic Toxicity | 1 |
Practical Considerations in the Conduct of Chronic | 53 |
Methods in Testing for Carcinogenicity | 79 |
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absorption acid activity agents analysis assay assessment ATPase behavior benzo(a)pyrene bioassay Biochem Biol blood body weight brain buffer cage cannula carcinogenic CCl4 cells centrifuged Chem chemical chronic clearance compound concentration cyclic AMP cytochrome P-450 detection determined dose levels drug effects enzyme evaluation excretion experimental exposure factors fluid function genetic glucose groups hepatic hepatotoxic homogenate hormone human incubation isolated perfused kidney laboratory animals lipid liver lung male measured membrane ment metabolism metabolites method mice microsomal mitochondria mouse mutagenic mutation nephron normal organ parameters patulin perfused Pharmacol phenobarbital Physiol plasma preparations procedure produce protein protocol quantitative rabbit rat liver reaction renal reproductive response rodents sample sensitive serum sodium solution specific studies subchronic substrate Table techniques teratogenic Teratology test article test substance tion tissue tive toxicity Toxicol toxicology transport tube tubular tumor urine vitro vivo volume