Virus Dynamics : Mathematical Principles of Immunology and Virology: Mathematical Principles of Immunology and VirologyOxford University Press, UK, 23 de nov. de 2000 - 250 páginas This groundbreaking book describes the emerging field of theoretical immunology, in particular the use of mathematical models to describe the spread of infectious diseases within patients. It reveals fascinating insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. Structured around the examples of HIV/AIDS and hepatitis B, Nowak and May show how mathematical models can help researchers to understand the detailed dynamics of infection and the effects of antiviral therapy. Models are developed to describe the dynamics of drug resistance, immune responses, viral evolution and mutation, and to optimise the design of therapy and vaccines. - ;We know, down to the tiniest details, the molecular structure of the human immunodeficiency virus (HIV). Yet despite this tremendous accomplishment, and despite other remarkable advances in our understanding of individual viruses and cells of the immune system, we still have no agreed understanding of the ultimate course and variability of the pathogenesis of AIDS. Gaps in our understanding like these impede our efforts towards developing effective therapies and preventive vaccines. Martin Nowak and Robert M May describe the emerging field of theoretical immunology in this accessible and well- written text. Using mathematical modelling techniques, the authors set out their ideas about how populations of viruses and populations of immune system cells may interact in various circumstances, and how infectious diseases spread within patients. They explain how this approach to understanding infectious diseases can reveal insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. The book is structured around the examples of HIV/AIDS and Hepatitis B virus, although the approaches described will be more widely applicable. The authors use mathematical tools to uncover the detailed dynamics of the infection and the effects of antiviral therapy. Models are developed to describe the emergence of drug resistance, and the dynamics of immune responses, viral evolution, and mutation. The practical implications of this work for optimisation of the design of therapy and vaccines are discussed. The book concludes with a glance towards the future of this fascinating, and potentially highly useful, field of study. - ;... an excellent introduction to a field that has the potential to advance substantially our understanding of the complex interplay between virus and host - Nature |
Conteúdo
1 | |
Dynamics of hepatitis B virus | 5 |
The basic model of virus dynamics | 34 |
Dynamics of immune responses | 52 |
How fast do immune responses eliminate infected cells? | 69 |
What is a quasispecies? | 86 |
The frequency of resistant mutant virus | 90 |
Emergence of drug resistance | 97 |
Advanced antigenic variation | 137 |
Multiple epitopes | 149 |
8 | 177 |
3 | 187 |
Analysis of multiple epitope dynamics | 196 |
55 | 208 |
References | 218 |
69 | 221 |
Termos e frases comuns
anti-viral antibody antigenic diversity antigenic variation basic model basic reproductive ratio Biol converge correlation cross-reactive immune response CTL response CTL-mediated lysis cytotoxic cytotoxic T cells decay denotes disease progression diversity threshold drug treatment epitope equations equilibrium virus load exponential fixed point free virus frequency genome half-life HIV infection human immunodeficiency virus immune responses immune system immunodominance immunogenic increase infected cells infected patients infected PBMC inhibitor initial lamivudine mathematical models model of virus multiple epitope mutant virus mutation rate n₁ Nowak oscillations PBMC Perelson produced protein provirus quasispecies R₁ replication rates resistant mutant resistant virus reverse transcriptase reverse transcriptase inhibitor saturated selective disadvantage sequence strain-specific immune responses T-cell target cells theory therapy uninfected variants viral virions Virol virus decline virus dynamics virus infection virus load virus mutants virus particles virus population viruses vivo wild-type virus y₁ zidovudine