Fundamentals of Analytical Toxicology

Capa
John Wiley & Sons, 2007 - 505 páginas
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The analytical toxicologist may be required to detect, identify,and in many cases measure a wide variety of compounds in samplesfrom almost any part of the body or in related materials such asresidues in syringes or in soil. This book gives principles andpractical information on the analysis of drugs and poisons inbiological specimens, particularly clinical and forensic specimens.

After providing some background information the book coversaspects of sample collection, transport, storage and disposal, andsample preparation. Analytical techniques - colour tests andspectrophotometry, chromatography and electro­phoresis, massspectrometry, and immunoassay – are covered in depth, and achapter is devoted to the analysis of trace elements and toxicmetals. General aspects of method implementation/validation andlaboratory operation are detailed, as is the role of the toxicologylaboratory in validating and monitoring the performance of point ofcare testing (POCT) devices. The book concludes with reviews ofxenobiotic absorption, distribution and metabolism,pharmacokinetics, and general aspects of the interpretation ofanalytical toxicology results.

  • A clearly written, practical, integrated approach to the basicsof analytical toxicology.
  • Focuses on analytical, statistical and pharmacokineticprinciples rather than detailed applications.
  • Assumes only a basic knowledge of analytical chemistry.
  • An accompanying website provides additional material and linksto related sites.

Written by an experienced team of authors,Fundamentals ofAnalytical Toxicology is an invaluable resource for thosestarting out in a career in analytical toxicology across a widerange of disciplines including clinical and forensic science, foodsafety, and pharmaceutical development. 

Praise from the reviews:

“This is an ambitious effort to describe in detail themany and varied aspects of the science of toxicological analysis.The 17 chapters cover every foreseeable aspect, from specimencollection through analytical techniques and quality control topharmacological principles and interpretation of results. Theauthors bring together a great deal of experience in the field andhave succeeded admirably in achieving their goal: "to giveprinciples and practical information on the analysis of drugs,poisons and other relevant analytes in biological specimens...".The book is very readable and quite up-to-date, and contains manyillustrative figures, charts and tables. Both the student and thepracticing professional would do well to study this materialcarefully, as there is something here for every conceivable levelof interest.”   Review from RandallBaselt

"This text comes highly recommended for any analyticaltoxicology trainee." The Bulletin of the Royal College ofPathologists

“Overall, this book provides a comprehensive, thorough,clear, up to date and practical treatment of analytical toxicologyat a high standard.  Understanding of the text is enhanced bythe use of many illustrations.  Specifications, guidelines,and methods are highlighted in grey background“Boxes”.  The many and up to date literaturereferences in each chapter demonstrate the authors’ thoroughwork and permit easy access to deeper information.  Thereforethis book can be highly recommended as a valuable source ofknowledge in analytical toxicology both as an introduction and forthe advanced reader.”  GTFCh Bulletin“Toxichem + Krimtech”, May 2008 (translated,original review in German)

“Many toxicologists will add this important referenceto their libraries because it competently fills a need...” International Journal of Toxicology

“The book is very well illustrated, easy to understandand pleasant to read, and contains a wealth of dedicatedinformation.” International Journal of EnvironmentalAnalytical Chemistry

 

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Conteúdo

Overview
1
Absorption Distribution Metabolism and Excretion of Xenobiotic
15
Sample Collection Transport and Storage
21
Sample Preparation
49
Colour Tests and Spectrophotometric and Luminescence Techniques
95
Introduction to Chromatography and Capillary Electrophoresis
117
ThinLayer Chromatography
131
Gas Chromatography
145
Mass Spectrometry
249
Trace Elements and Toxic Metals
281
Immunoassays and EnzymeBased Assays
309
Toxicology Testing at the Point of Care
339
Basic Laboratory Operations
353
Pharmacokinetics
431
Clinical Interpretation of Analytical Results
463
Index 495
553

HighPerformance Liquid Chromatography
177
Capillary Electrophoretic Techniques
231

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Sobre o autor (2007)

Robert J. Flanagan. King's College Hospital NHS FoundationTrust, London, UK

Andrew Taylor. Royal Surrey County Hospital, UK

Ian D. Watson. Aintree Hospitals, Liverpool, UK

Robin Whelpton. Queen Mary, University of London, UK

Informações bibliográficas