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I have ascertained by experiment more took sixty drops of the eau medicinale, than six times upon nigreif: at one the pain of the gout was insufferable, time the symptoms went off in six I got into bed, and was so chilly as not hours, at another in twelve, and at to be able to keep my hands warm, ered others in twenty-four hours.
under the bed clothes. lo two hours As we know the sensible effects of I became rather hot and thirsty. In mercury, whether it is introduced into three hours the pain was so much dimithe circulation by the absorbents, or nished as to be tolerable, while the received into the stomach, are the limb was at rest. In seveg hours I had same, we conclude, whenever these sen- a confined motion from the bowels, sible effects are met with, that mer- and the pain in the ankle became severe, cury is actually in the circulation. while the foot was placed on the ground,
If therefore occurred to me, that if but this went off as soon as the foot the sensible effects of the infusion of the was again placed in a horizontal poscolchicum should prove to be the same, ture. A nausea, or halı sickness came wbether it is introduced into the circu- on; my pulse wbich is naturally eighty Jation by the jugular vein, or received in a minute, was lowered to sixty, and by the mouth into the stomach, that we intermitted in ten bours, the nausea might equally in both cases conclude it was gone off, but I remained languid to be in the circulation. To delermine the pulse beating seventy in a minute. this point, thirty drops of the vinonsin- 1 bad soine appetite for food. fusion of the colchicum i made by ma- The following mornivg my pulse was cerating two pounds of the fresh roots eighty, and baring passed a good night, in twenty-four ounces of sherry wine, I was enabled to walk as usual, and in a gentle heal for six days, the spirit follow the duties of my profession. If being previously carried off hy heat) these observations shall be confirmed was diluted with a dram of water, and they must lead us to conclude, that the conveyed into the circulation of a mo. different kinds of substances, which derately sized dog by the jugular vein. produce specific diseases, are first cara The dog's pulse in a natural state is 140 ried into the circulation in the sams in a minute.
maliner as mineral and animal poisons, In five bours the dog had a tremulous and that the medicines by which they motion of the muscles and fiuttering of are acted upon, go through the same the pulse, accompanied with nausea, but course before they produce their beneno retching to vomit. In fourteen mi- ficial effects, a material step will thus nutes the pulse was 180 in a minute,' be gained in the consideration of and had frequent intermissions. In four diseases, and the modes of treating bours the pulse was 120 a ininute, of them. its natural strength, and had frequent interioissions. In seven hours the dog had a natural motion, the pulse had no intermission, was 140 in a minute. The dog bad a good appetite for food and appeared in perfect health.
Read April 21, 1816. The same dog at the end of three When I laid before the society my complete days, swallowed sixty drops of paper upon this subject, I was anxious the same infusion, exactly double the to establish what appeared to me to be quantity that had been introduced into two important facts; one that the infu. the circulation. In two hours he he- sion of the colchicum can be received caine languid, the pulse wiry and weak, into the circulation without produciug but 140 in the minute. In four hours any pernjanent mischief; the other is, and a half the langour much less, and that through the medium of the cir. the pulse natural. In eight bours the culation its beneficial effects upon gout dog bad had a natural motion. In are produced, and therefore, the sudden eleven hours was in good spirits and relief which is experienced cau be rea
dily explained. The sensible effects opon the dog, Having attended to the effects of the were similar to those produced upon cau medicinale, and for this medicine myself, but in a less degree. Under for several years in cases of gout, both the influence of a violent fit of the in my own case and in those of my gout in the ankle, on the 233 of Dec. friends, I found invariably, that they 1813, at ten o'clock in the morning, I diminished the frequency of the pulsa
AN APPENDIX TO A PAPER ON THE
EFFECTS OF THE COLCHICUM AUTUN.
ten or twenty beats in a minute, and this Io five hours, vomited some bloody effect generally took place about twelve mucus, and expired. hours after the medicine was exhibited: On openiog the body, the stomach I therefore considered this to be the contained mucus tinged with blood, and criterion of the constitution being under its internal membrane was inflamed ; the influence of the medicine; and the duodenum had its internal surface #hen I found that the pulse was affected universally inflamed; the same appear. in the same way by the medicine receiv- ance in a less degree was met with in ed into the circulation, and in a much the jejunium and ilium, and more shorter time, I became satisfied that in strongly marked in the colon than in both cases this arose from an effect upon the ilium. the circulation and not upon the sto- The facts which I have now adduced mach, and therefore did not further pro- afford sufficient proof of the action of secute the inquiry : since exbibiting the colcbicum autumnale upon the diflarger doses could only confirm what is ferent parts of the body, being through already known; namely, that the medi. the medium of the circulation, and not cine is capable when injudiciously used, in consequence of ts immediate effects of producing very violent effects. upon the stomach and jutestines.
It has been suggesied to me, since the Paper was read, that the only mode of proving that the medicine acts through
RECIPES. the medium of the circulation, is to
No. XII. show, that when a sufficient quantity is received into the blood, all the vio Tolhe Editor of the European Magazine. leat effects are produced that result from a large dose taken by the mouth ; AM
MONG many other of your valuand as I had no object but the pursuit
able Recipes, to class one that of truth. I lost no time in complying shall be proved a most effective and with this suggestion, and introduced infallible cure for chilblains and chapped into the circulation of a dog 160 drops hands, may not be found useless, partiof the same infusion before employed.
cularly at this season of the year, to The animal instantly lost all power
some of your numerous readers It is of voluntary motion, the breathing be nothing more than night and morning came extremely slow, and the pulse was
fomenting the parts affected with strong hardly to be felt. In ten miöntes the brine (in which enll petre has been used) pulse was e ghly four, the inspirations
as hol as can be borne. Once or twice natural, which are forty in a minute; for the hands, when chapped, is genein lwenty minutes the pulse was sixty, rally found sufficient. I have known the inspirations thirty in a minute, chilblains, when extremely swelled and a tremulons motion had taken place in black, appearing as if vot any thing the hind legs, in an hour the pulse was
could hinder them from breaking, in 115 and irregular, the animal was capa
a short time entirely removed. If its ble of sitting up but was in a state of simplicity should recommend it for inviolent tremour, and the inspirations sertion, it will oblige could not be counted. in one hour
EXPERIENCE. and a half the tremeur had gone off, London, 11th Dec. 1816. the polse continued the same; the ani. P.S. It may not be unnecessary to' mal made ineffectual attempts to vomit, add, the application should be by the and continued to do so for ten minutes fire, and be held there until the parts accompanied with great langour, the are quite dry. inspirations were fifty-four in a mi. nute.
In two bours, the pulse was 150, and very weak ; the animal had voided one Take of volatile tincture of guns ounce and a half of water, had vomited guiacum, sweet spirits of nitre, balsam twice, each time bringing up a quantity of capivi, and oil of juniper, in equal of mucus tinged with bile, and had two quantities. One tea-spoonful in a wine liquid stools.
glass of gio and water, or warm grucl, in In three hours, had vomited again, the morning fasting; repeat the dose at and had another stool; the pulse too noon, and again between dinner and weak to be coupted.
supper, but not late in the evening, In four hours, continued extremely as some exercise should be taken, if languid.
possible, after the dose.
FOR THE LUMBAGO.
MISCELLANEOUS INFORMATION. 1646 to 1676
266,358 No. XXXII.
1676 to 1682
.270,313 PROGRESSIVE EXTENT OF THE RUSSIAN
1689 to 1725
1725 to 1740
.324,546 THE THE following account of the pro- 1740 to 1762
.324,588 gressive extension of the Russian 1762 to 1796
336,632 Empire, which we have given in geo
1796 to 1801
.335,633 grapbical miles, may not be unaccept- 1801 to 1811
-.340,899 able to a large portion of our readers. As a geograpbical mile comprehends From 1462 to 1505, the Empire
21 2-9ths English, this prodigious Emcomprised territories compre- pire, in 1811, comprised upwards of hending
30,566 7,200,000 square iniles! It appears, From 1505 to 1534
40,155 therefore, that in the course of little 1534 to 1594
145,020 more than three centuries, it has in1584 to 1598
..151,494 creased to about eighteen times its ori1598 to 1645
257,805 ginal extent ! Amount of the Capitals at the Bank, South Sea, and India House, Oct. 1, 1916.
Interest, £. S. d.
d. *Bank Stock, at 10 per cent. ... 11,686,800 0 0 1,168,680 0 0 Added to ditto, since Feb. I, 1816 (for
which Government is to pay 3 per cent. 3,000,000 0 0 90,000 0 0 +South Sea Stock, 3 per cent.
3,662,784 8 6 128,197 10 0 per cent. Old Aon. 11,907,470 2 7 357,224 20
3 per cent, New Ann. 4,500,830 2 10 135,024 18 0 % per Cents. Navy
.134,900,057 97 6,745,002 11 54 5 per Cents, 1797 and 1802
1,281,630 5 2 64,081 10 3 4 per Cents.
74,933,719 2 2 2,997,428 15 31 3 per Cent. Consols
-398,323,514 7 93 11,949,705 8 7 3 per Cent. Reduced
.189,255,478 5 9 5,677,664 611 $ per Cent. 1726
1,000,000 0 0 30,000 0 0 % per Cent. 1751
966,600 0 0
29,998 0 0 Imperial 3 per Cents...
7,502,033 6 8 225,079 0 0% Annuities, ending May 1, 1819
230,000 0 0 Long Anouities, to expire 5th Jan. 1860
1,359,435 18 81 Lite Annuities, due 5lb Jan. and 5th July
108,371 16 6 Life Aunuities, due 5th April & 10th Oct.
91,473 3 6
842,923,517 10 6 31,386,367 34
*India Stock, at 10% per cent.
6,000,000 0 0 630,000 0 0 Stock purchased for the Reduction of the National Debt between Aug. 1, 1806, and
Aug. I, 1816.
187,955,061 00 3 per Cent. Covsois.
94,283,392 0 0 9 per Cent. Old South Sea Annuities.
5,990,900 00 3 per Cent. New Ditto .
4,400,000 0 3 per Cent. 1751 aod 1726
1,004,000 0 0 Imperial 3 per Cent.
1,845,426 0 0 5 per Cent.
145,500 0 0 4 per Cent.
303,420,679 0 0 To be deducted from the above Capitals, and wbich has cost in money 190,644,6321. 178. lld. Land Tax redeemed to February 1, 1816, 25,155,0561. 198. 31. to be deducted from the above capitals.
The interest of Bank Stock is paid as follows: 3 per cent, by the Government, and 7 per cent. by the profits of the trade of the Bank of England; and the capital is a charge opon the public.
+ 'The interest of į per cent, upon Sonth Sea Stock is paid by the Company; the remainder, with the capital, is a charge upon Government.
# The capital and interest of East India Stock are payable by that Company.
FOR DECEMBER, 1816.
QUID SIT PULCHRUM, QUID TURPE, QUID UTILE, QUID non.
I , ,
The Speech of Thomas Fowell Bu.xlon, This was the effect which rewarded
Esq. at the Egyplian Hall, on the the earnestness of the speaker at the 26th November, 1816, on the subject time that he delivered it; and this is of the Distress in Spital Fields, lo the result which has followed his hu. which is added in Report of the mane effort. Spital Fields Association read at the The cause indeed of itself possessed Meeting Published by Order of the sufficient interest to call forth all the Committee then appointed, and for the spontaneous exertions of the humane Benefit of its Funds. 8vo.
and generous, in behalf of the misera. T has been said by an elegant writer ble sufferers ; but, urged as it has been, tary principles of eloquence are to be guage breathes the most elevated senfound in the sympathics of the heart.* timents of a manly sensibility, it has This is a very rational opinion, which been met by the most comprehensive both the purpose and the property of measures of relief and remedy: eloquence substantiale.
In the noble subscription which has of eloquence is, to prove a necessity been made for the succour of the disfor its interference, and to secure the tressed multitudes, whose wretched neaccomplishment of its object. Its pro- cessities and suffering patience this perly comprehends those qualities by speech represents so truly, and pleads which its purpose inay be made more so ably, we bear testimony to that evident to the judgment of the persons prompt beneficence of Englishmen, addressed, and their inclinations conci- which makes the cause of sorrow its liated to meet the speakers' views; and own, and instantly applies its healing as eloquence can only then be genuine, hand to bind 'up the wounds, and aswhen it is made the medium of truth, suage the pangs of those who, in the he that speaks from the natural influ- Janguage of holy writ, "go mourning once of the best feelings of the heart, all the day long.” To the deplorable will speak eloquently even without the case of the Spital-fields' poor, so paadventitious aid of alstract disquisi- thetically described by Mr. Buxton, tion, or profound learning.
this expression peculiarly applies ; their It is on these grounds that we pre.. griefs were of no common sort--sorrow sent this address to our readers, with the is but a feeble characteristic of their character of an eloquent speech--for it misery-every afflictive burthen that embraces all the requisites which could could weigh down the spirits, and make it impressive to those who heard plunge the whole man, mind and body, it, and interesting to those who read into the lowest depths of wretchedness, it. "The truths which it declares, and had " seized fast hold upon them. Want the cause which it pleads, demand our: had come upon them like an armed attention and constrain our concur- man,” and well pigb crushed every rence: it does more, it excites our com- physical and mental power, every dopassion, and blends the subject of the mestic consolation, every possession, speech with our tenderest regrets. The and every hope in its ruthless grasp. facts we lament, the cause we acknow. But no sooner was this extreme indi. ledge, and the means of alleviation we gence made known, through a medium are anxions to provide, at the same in which the efficacy of aid could be instant in which we are made acquainted most amply secured, than that aid was with both.
bestowed.--and to the everlasting bo* Melmoth.
our of the inhabitants of this meiro. Europ. Jng. Hul. LXI. Dec. 1810.
polis be it mentioned, that notwith- affection for their country, and their standing the straits and difficulties to disinterested vindication of her liberwhich ihey bave themselves been sub- ties, cau without a sigh of pity or a jected, by the depression of their com- mite of relief, convert the sufferings of mercial dependencies, and by their in- poverty, and the afflictions of privation, dividual privations, the cry of the poor io their own insidious purposes of rewas heard with all that unteigned coni- bellion and subversion.-But we forbear, miseration, and that charitable eager- because we differ in toto from their ness to afford immcdiate assistance, sense of the evils which our labouring which mark the pre-eminent liberality poor endure; and because we think, thai of the Merchants and Tradesmen of compassionate relief is a much inore London.-Their munificent gifts are efficacious remedy for those evils, thao already put into action, and the season. that irritation which such persons seem able supplies which they have produced, so studiously to excite, and the incohave been as promptly administered, as rable calamities wbich they appear to those gills were bestowed. The naked bo rashiy disposed to produce. are clothed, the hungry fed, aird the We now return to the address before sick are in a progress to recovery; pa. us, and with the observation of a Grerents and children, and infants that cian orator upon the successful speech of hung at the exhausted breasts of their his eloquent competitor, we introduce il drooping mothers, have received pew to our readers:— * Ifyou so much admiro life. The clouds of despondency are it as you read it, your admiration would dissipated-lhe sinews of industry are have known no bounds had you heard him restored to their wonted vigour, and deliver it.”—The pathos and the well the independent earoings of virtuous regulated animation with which Mr. toil are returning to their accustomed Buxton spoke, could only be exceeded channels.
in effect, by the good sense and forcible These are the best consequences that arguments of the speech itself. the most sanguine hopes of those who The unaffected modesty which tempromoted and supported the meeting pered the warmth of his feelings is at the Egyptian Hall could either con- strongly evidenced in the opening of template in expectation, or desire in the address. eifect.
MY LORD, To the Lord Mayor who called the “ As one of the persons who were in ineeting, and who so essentially con- strumental in convening this Meeting, duced by his judicious opening of the it has been intimated to me that it is business, to that unanimity of princi- my duty to explaiu our objects. This, ples which gave an effective union of and this alone, I can truly say, has urged design to the measure, the highest tri- me to place myself in a situation mors bule of respectful acknowledgment is prominent and more considerable than d:10-Never were well constituted minds any other circumstance would warrant. occupied in a better work, and never It has been my lot to see something of was the influence of magisterial autho- the distress that rages in our unhapp! rily more ingenuously, and more bene- district: and whoever had seen, as I ficially applied. The example which have seen, the utmost ravages of hun. was thus set by the City of London, ger, coid, and disease-whoever bad and thus made operalive of all the pro- witnessed, as I have wituessed within jected good by its excellent Chief these few hours, the decrepitude of age Magistrale, has given an impulse of without ove of those many comfort: earnest consideration and generous which may alleviate its natural privaaction to all the parishes in London tions ;-without the common pecessa: aus Westminster--and it is with heart- ries of life-food, fuel, clothing-bad full sati faction that we bear witness to witnessed (perhaps the most affecting of the voiversal co-operation withi which all spectacles)--the despair, the fixed. such benevolent exertious have been the downcast, the prostrate despair of corded.
manhood willing to work, but unable to It would be excusable were we to obtain employment, and compelled to advert to the superior claim of real see in the countenance of his dejected patriotism, which such plans, and such wife, and to liear in the cries of his execution of them, might well chal. perishing children, the consequences ledige over the cold-hearted sophistries of his arrested loil:—wboever, in short, ljnose who wanting of their ariçot had been doonied to thc unhappy whicu