Receptors: Models for Binding, Trafficking, and SignalingOxford University Press, 5 de ago. de 1993 - 376 páginas Receptors: Models for Binding, Trafficking, and Signaling bridges the gap between chemical engineering and cell biology by lucidly and practically demonstrating how a mathematical modeling approach combined with quantitative experiments can provide enhanced understanding of cell phenomena involving receptor/ligand interactions. In stressing the need for a quantitative understanding of how receptor-mediated cell functions depend on receptor and ligand properties, the book offers comprehensive treatments of both basic and state-of-the-art model frameworks that span the entire spectrum of receptor processes--from fundamental cell surface binding, intracellular trafficking, and signal transduction events to the cell behavioral functions they govern, including proliferation, adhesion, and migration. The book emphasizes mechanistic models that are accessible to experimental testing and includes detailed examples of important contemporary issues. This much-needed book introduces chemical engineers and bioengineers to important problems in receptor biology and familiarizes cell biologists with the insights that can be gained from engineering analysis and synthesis. As such, chemical engineers, researchers, and advanced students in the fields of biotechnology, biomedical sciences, bioengineering, and molecular cell biology will find this book to be conceptually rich, timely, and useful. |
Conteúdo
3 | |
9 | |
3 ReceptorLigand Trafficking | 73 |
4 Physical Aspects of ReceptorLigand Binding and Trafficking Processes | 133 |
5 Signal Transduction | 181 |
6 ReceptorMediated Cell Behavioral Responses | 236 |
7 Future Directions | 360 |
362 | |
Outras edições - Ver todos
Receptors: Models for Binding, Trafficking, and Signaling Douglas A. Lauffenburger,Jennifer Linderman Visualização parcial - 1996 |
Receptors: Models for Binding, Trafficking, and Signaling Douglas A. Lauffenburger,Jennifer J. Linderman Visualização parcial - 1996 |
Termos e frases comuns
activity adenylate cyclase affinity analysis antigen assay attractant concentration Biophys bivalent bond bound receptors C₁ Ca2+ calcium cell adhesion cell behavioral Cell Biol cell surface receptors cellular Chem chemotactic coated pits coated-pit compartment complex number contact area coupling crosslinking curve cytoplasmic degradation density dimensionless dissociation constant dissociation rate constant dynamics effects EGF receptor EGF-R endocytic endocytosis endosome enzyme epidermal growth factor equations experimental data fibroblasts force fraction free receptors function G-proteins gradient increases integrins interactions intracellular k₁ kinase kinetic lamellipodal Lauffenburger ligand binding ligand concentration macrophages mathematical models mechanism molecular molecules monovalent motile multivalent neutrophil number of receptors oscillations parameter values pathway peptide predictions protein quantitative R₁ rate constant ratio receptor and ligand receptor binding receptor number receptor-mediated receptor/ligand binding receptor/ligand complexes recycling response result Scatchard plot second messenger signal transduction ternary complex total number trafficking Tranquillo tubules unlabeled ligand uropodal vesicle Zigmond
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