Computational Structural Biology: Methods And ApplicationsTorsten Schwede, Manuel C Peitsch World Scientific, 2 de mai. de 2008 - 792 páginas Computational structural biology has made tremendous progress over the last two decades, and this book provides a recent and broad overview of such computational methods in structural biology. It covers the impact of computational structural biology on protein structure prediction methods, macromolecular function and protein design, and key methods in drug discovery. It also addresses the computational challenges of experimental approaches in structural biology. In addition to reviewing the current state of computational structural biology, each chapter ends with a brief, visionary discussion on the future outlook, whereby the main challenges for the coming years are elucidated. Written by an international panel of expert contributors, this book can serve as a reference manual for students and practitioners alike. |
Conteúdo
Section II FROM STRUCTURE TO FUNCTION TO DESIGN | 129 |
Section III DRUG DISCOVERY AND PHARMACOLOGY | 467 |
Section IV NEW FRONTIERS IN EXPERIMENTAL METHODS | 599 |
Section V SELECTED TOPICS | 681 |
| 771 | |
Outras edições - Ver todos
Computational Structural Biology: Methods and Applications Manuel Claude Peitsch Visualização parcial - 2008 |
Computational Structural Biology: Methods and Applications Torsten Schwede Visualização parcial - 2008 |
Termos e frases comuns
Acad Sci USA accuracy active algorithm alignment AMBER TIP3P amino acid analysis antibody approach assessment atoms automated binding affinity binding sites Bioinformatics biological Biophys calculations catalytic CATH cell Chem Chem Phys complex compounds conformational coordinates crystal structures Crystallogr crystallography database determined developed diffraction docking domain drug electron electrostatic ensemble enzyme epitopes experimental fold recognition force field free energy homology hydrogen bonds hydrophobic interactions JAm Chem Soc ligand loop macromolecular MD simulations mechanism methods Mol Biol molecular dynamics molecular dynamics simulations molecules motions Natl Acad Sci Nucl Acids Res parameters peptides pharmacophore potential Proc Natl Acad protein folding Protein Sci protein structure models protein structure prediction protein-ligand receptor refinement residues RMSD sampling scoring functions secondary structure sequence identity server side-chain solvation solvent stability Struct Biol structural genomics structure-based surface target tein template tion transition tures X-ray crystallography