Clinical Trials: A Practical Guide to Design, Analysis, and Reporting

Capa
Remedica, 2006 - 480 páginas
The author takes a back-to-basics approach to explaining statistics specifically for a medically literate audience. Each article provides essential background information to each topic, explores its meaning, and explains how and when it should be applied. Medical students, statistics students, clinical researchers, pharmaceutical sales representatives Statistics are complicated, but to a large extent this is a reflection of the way in which they are taught. In this book, Dr Bahkar takes a back-to-basics approach to explaining statistics specifically for a medically literate audience. Based on the successful "Practical Issues in Clinical Trial Design" series published in Remedica's flagship journal Clinical Researcher, and supplemented by key contributions from other leading international experts, each article provides essential background information to each topic, explores its meaning, and explains how and when it should be applied. Readers will gain not only an understanding of the basics of medical statistics, but also critical insight into how to review and evaluate clinical trial evidence.
 

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Conteúdo

Introduction
IntentiontoTreat Analysis 255
Subgroup Analysis 265
Randomized Clinical Trials 1
Patient Selection 47
Randomization 65
Crossover Trials 91
Equivalence Trials 113
Repeated Measurements 317
Multiplicity 329
Missing Data 339
Interim Monitoring and Stopping Rules 353
Reporting of Trials
Overview of Reporting 365
Trial Profile 377
Presenting Baseline Data 385

Cluster Randomized Trials 141
Types of Data and Normal Distribution 167
Significance Tests and Confidence Intervals 185
Comparison of Means 197
Analysis of Survival Data 235
Regression Analysis 273
Adjustment for Covariates 287
Confounding 295
Use of Tables 391
Use of Figures 407
Critical Appraisal of a Report 427
MetaAnalysis 439
Glossary 453
Abbreviations 461
Index 467
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